Sublingual immunotherapy (SLIT) has been studied for over 30 years worldwide. OLLEREG brings this science to your doorstep — no clinic visits, no injections.
Oral immunotherapy — also called sublingual immunotherapy (SLIT) when delivered under the tongue — is a medical treatment that gradually desensitizes your immune system to specific allergens. Instead of avoiding allergens or masking symptoms with antihistamines, OIT addresses the root cause: an immune system that overreacts to harmless substances like pollen, pet dander, or dust mites.
The principle is simple: expose the immune system to tiny, gradually increasing doses of the allergen, and over time it learns to tolerate it. This is the same principle behind allergy shots (subcutaneous immunotherapy), but delivered painlessly as an oral spray.
What happens inside your body each time you use OLLEREG
When you spray OLLEREG under your tongue, the allergen proteins are absorbed through the sublingual mucosa — a thin, highly vascularized tissue. This region is uniquely rich in Langerhans cells and dendritic cells, which are antigen-presenting cells (APCs) that serve as the first line of immune recognition.
Dendritic cells capture the allergen and migrate to nearby lymph nodes, where they present allergen fragments to naive T-cells. Because the dose is tiny and the sublingual route favors tolerance, these T-cells are biased toward a regulatory phenotype rather than an allergic one.
In allergic individuals, the immune system produces high levels of IgE antibodies, which trigger mast cells to release histamine — causing sneezing, itching, and congestion. Over months of OIT, the immune system shifts: IgE production decreases while IgG4 — a "blocking" antibody — increases. IgG4 intercepts the allergen before it can bind to IgE, effectively neutralizing the allergic cascade.
Perhaps the most important change: OIT promotes the growth of regulatory T-cells (Tregs). Tregs produce anti-inflammatory cytokines (IL-10, TGF-beta) that suppress the Th2-driven allergic response. Over time, Tregs create a durable state of immune tolerance — your body genuinely learns that the allergen is not a threat. This is why the effects can last even after treatment ends.
OLLEREG follows a carefully designed dose escalation schedule. Each month, your spray contains a slightly higher concentration of allergen extract — gradually increasing the challenge to your immune system while staying well within the safe range.
Maintenance dose is typically reached at approximately 6 months. Treatment continues at this dose for a minimum of 3 years — the threshold where clinical research shows lasting immune remodeling. Many patients continue to experience reduced symptoms even years after completing treatment.
OLLEREG also contains a patent-pending natural adjuvant that enhances immune tolerance — a unique formulation found only in OLLEREG, developed by Dr. Dat Tran.
Sublingual immunotherapy has been studied extensively since the 1990s, with thousands of peer-reviewed studies across Europe, Asia, and the Americas. The World Allergy Organization (WAO) and the European Academy of Allergy and Clinical Immunology (EAACI) both endorse SLIT as a safe and effective treatment for allergic rhinitis, allergic asthma, and specific allergen sensitivities.
Clinical trials consistently show that approximately 80% of SLIT patients experience meaningful symptom reduction. The sublingual route carries a significantly lower risk of systemic reactions compared to injection-based immunotherapy — most patients report only mild, transient oral itchiness during the initial weeks of treatment.
Choose the spray that matches your allergies and start building tolerance today.
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